HYBRID EVENT: You can participate in person at Singapore or Virtually from your home or work.
Morgan Donnard, Speaker at Catalysis Conferences
CNRS – University of Strasbourg, France
Title : Captodative Enamides: from Controlled Syntheses to Original Heterocycles

Abstract:

Enaminals are valuables building blocks in organic synthesis as they open the door to a wide range of more complex structures such as polyfunctionalized heterocycles or act as precursors of unconventional ? and ???? amino-acids for instance. Noteworthy, both regioisomers (? or ???? enaminals) are appealing as they allow access to different molecular edifices. If ????-enaminals, being valuable push-pull building blocks, have been well studied in the past, ?-enaminals, having this time a captodative character, have been much less investigated and remain really complex to obtain, especially if you target tri- or tetra-substituted scaffolds with complete control of the regio- and stereo-chemistry. During the past few years we have developed diverse methodologies based on carbonylation and silylation reactions on ynamides to obtain versatile enaminal derivatives. Notably these methodologies are highly stereo- and regio- controlled. Among the reactions that will be introduced, we will present the first examples of regiodivergent hydroformylation of alkynes which are totally controlled by the nature of the ligand used. In addition we will also introduce the controlled synthesis of various silylated enaminal-derivatives as well as their post-functionalization leading to a wide scope of original and valuable building blocks. Nicely, these new compounds open the door to rapid and efficient syntheses of original heterocycles.

Audience take-away:

  • How to control efficiently, thanks to the catalytic conditions, the difunctionalization of ynamides.
  • How to control the dual character (electrophilic & nucleophilic) of captodative enaminals.
  • The potential of captodative enamines as building blocks in organic synthesis

Biography:

Morgan Donnard obtained his PhD in organic chemistry in 2008 under the supervision of Pr. Jacques Eustache at the Ecole Nationale Supérieure de Chimie in Mulhouse (ENSCMu). He then joined the group of Pr. Jonathan Clayden in Manchester as Post-Doctoral Research Associate where he stayed 2 years. At the beginning of 2011 he came back to France for a second post-doctoral stay in the team of Dr. Nicolas Blanchard (ENSCMu) . In 2012 he was offered a CNRS Research Associate (Ass. Prof.) position at the university of Strasbourg. He obtained his habilitation in 2019.

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